Risk of Venous Thromboembolism with Antipsychotics

 In Pharmacy Information, Regulations and Standards


A risk of venous thromboembolism for patients treated with antipsychotics has been suspected for some time.

A recent study (BMJ 2010;341:c4245) has confirmed that the increased risk is about four extra cases per year for every 10,000 patients treated, and ten extra cases for patients over 65 years old.

It is recommended that risk factors for venous thromboembolism should be identified for each patient before and during treatment with antipsychotics and appropriate preventative measures taken. Risk factors include obesity, metabolic syndrome, HRT, oral contraception (with oestrogen), and dehydration.

There is a NICE clinical guideline (CG92) on minimising the risk of venous thromboembolism.

Discussions with patients regarding the risks and benefits of their treatment should include appropriate information.

Risk assessment tool (NICE CG92):http://guidance.nice.org.uk/CG92/BaselineAssessment/xls/English

By BruceBlaus. Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. (Own work) [CC BY 3.0 (http://creativecommons.org/licenses/by/3.0)], via Wikimedia Commons

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