MHRA Drug Safety Update: Valproate in Pregnancy

 In MRHA News and Safety Alerts

Covers new important information and strengthened warnings about the epileptic drug Valproate.

Details include:

  • children exposed in utero to valproate are at a high risk of serious developmental disorders and/or congenital malformations
  • valproate should not be prescribed to women who are pregnant or of childbearing potential unless other treatments are ineffective or not tolerated
  • valproate treatment must be started and supervised by a doctor experienced in managing epilepsy or bipolar disorder
  • the benefits of treatment should be carefully balanced against the risks when prescribing valproate for the first time. Female patients must be made aware of the risks.

By en:User:Sponge [GFDL ( or CC-BY-SA-3.0 (], via Wikimedia Commons


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